De-Escalation Strategies in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Early Breast Cancer (BC): Final Analysis of the West German Study Group Adjuvant Dynamic Marker-Adjusted Personalized Therapy Trial Optimizing Risk Assessment and Therapy Response Prediction in Early BC HER2- and Hormone Receptor-Positive Phase II Randomized Trial-Efficacy, Safety, and Predictive Markers for 12 Weeks of Neoadjuvant Trastuzumab Emtansine With or Without Endocrine Therapy (ET) Versus Trastuzumab Plus ET.

Harbeck, Nadia

De-Escalation Strategies in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Early Breast Cancer (BC): Final Analysis of the West German Study Group Adjuvant Dynamic Marker-Adjusted Personalized Therapy Trial Optimizing Risk Assessment and Therapy Response Prediction in Early BC HER2- and Hormone Receptor-Positive Phase II Randomized Trial-Efficacy, Safety, and Predictive Markers for 12 Weeks of Neoadjuvant Trastuzumab Emtansine With or Without Endocrine Therapy (ET) Versus Trastuzumab Plus ET. [electronic resource] - Journal of clinical oncology : official journal of the American Society of Clinical Oncology Sep 2017 - 3046-3054 p. digital

Publication Type: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial

1527-7755

10.1200/JCO.2016.71.9815 doi


Ado-Trastuzumab Emtansine
Adult
Antibodies, Monoclonal, Humanized--therapeutic use
Antineoplastic Combined Chemotherapy Protocols--therapeutic use
Biomarkers, Tumor--metabolism
Breast Neoplasms--drug therapy
Female
Humans
Maytansine--analogs & derivatives
Middle Aged
Neoadjuvant Therapy
Precision Medicine--methods
Prospective Studies
Receptor, ErbB-2--biosynthesis
Trastuzumab