Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function.

Zhang, Chi

Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function. [electronic resource] - Nature communications 07 2017 - 16050 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2041-1723

10.1038/ncomms16050 doi


ATPases Associated with Diverse Cellular Activities--metabolism
Animals
Blood-Brain Barrier--metabolism
Endocytosis
Endosomal Sorting Complexes Required for Transport--metabolism
Endosomes--metabolism
Endothelial Cells--metabolism
Eye Diseases, Hereditary--genetics
Eye Proteins--genetics
Familial Exudative Vitreoretinopathies
Frizzled Receptors--genetics
HEK293 Cells
HeLa Cells
Humans
In Vitro Techniques
Lysosomes--metabolism
Mice
Multivesicular Bodies--metabolism
Mutation
Neovascularization, Physiologic
Nerve Tissue Proteins--genetics
Protein Transport
Retina
Retinal Diseases--genetics
Retinal Vessels--growth & development
Ubiquitination
Vacuolar Proton-Translocating ATPases--metabolism
Wnt Signaling Pathway