Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity.

Honda, Kuniya

Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity. [electronic resource] - Pain Sep 2017 - 1754-1764 p. digital

Publication Type: Journal Article

1872-6623

10.1097/j.pain.0000000000000973 doi


Acetanilides--pharmacology
Animals
Disease Models, Animal
Enzyme Inhibitors--pharmacology
Freund's Adjuvant--toxicity
Glutamic Acid--metabolism
Glycine--analogs & derivatives
Hyperalgesia--etiology
Male
Neurons--drug effects
Pain--chemically induced
Pain Threshold--drug effects
Phenylacetates--pharmacology
Physical Stimulation--adverse effects
Purines--pharmacology
Pyridines--pharmacology
Rats
Rats, Sprague-Dawley
Receptor, Metabotropic Glutamate 5--metabolism
Signal Transduction--physiology
Skin--innervation
TRPA1 Cation Channel--antagonists & inhibitors
TRPV Cation Channels--antagonists & inhibitors
Thiazoles--pharmacology
Trigeminal Ganglion--cytology