Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity.

Salvat, Regina S

Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America 06 2017 - E5085-E5093 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1091-6490

10.1073/pnas.1621233114 doi


Algorithms
Humans
Mutation
Neoplasm Proteins--genetics
Neoplasms--genetics
Peptide Library
beta-Lactamases--genetics