A Phase Ib Dose-Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Cobimetinib and Duligotuzumab in Patients with Previously Treated Locally Advanced or Metastatic Cancers with Mutant KRAS.
Lieu, Christopher H
A Phase Ib Dose-Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Cobimetinib and Duligotuzumab in Patients with Previously Treated Locally Advanced or Metastatic Cancers with Mutant KRAS. [electronic resource] - The oncologist 09 2017 - 1024-e89 p. digital
Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study
1549-490X
10.1634/theoncologist.2017-0175 doi
Acneiform Eruptions--epidemiology
Administration, Oral
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Asthenia--epidemiology
Azetidines--pharmacology
Colorectal Neoplasms--drug therapy
Dose-Response Relationship, Drug
Drug Eruptions--epidemiology
ErbB Receptors--antagonists & inhibitors
Female
Humans
Hypokalemia--epidemiology
Immunoglobulin G--pharmacology
MAP Kinase Kinase 1--antagonists & inhibitors
Male
Middle Aged
Neoplasm Staging
Piperidines--pharmacology
Prospective Studies
Proto-Oncogene Proteins p21(ras)--genetics
Receptor, ErbB-3--antagonists & inhibitors
Signal Transduction--drug effects
Treatment Outcome
A Phase Ib Dose-Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Cobimetinib and Duligotuzumab in Patients with Previously Treated Locally Advanced or Metastatic Cancers with Mutant KRAS. [electronic resource] - The oncologist 09 2017 - 1024-e89 p. digital
Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study
1549-490X
10.1634/theoncologist.2017-0175 doi
Acneiform Eruptions--epidemiology
Administration, Oral
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Asthenia--epidemiology
Azetidines--pharmacology
Colorectal Neoplasms--drug therapy
Dose-Response Relationship, Drug
Drug Eruptions--epidemiology
ErbB Receptors--antagonists & inhibitors
Female
Humans
Hypokalemia--epidemiology
Immunoglobulin G--pharmacology
MAP Kinase Kinase 1--antagonists & inhibitors
Male
Middle Aged
Neoplasm Staging
Piperidines--pharmacology
Prospective Studies
Proto-Oncogene Proteins p21(ras)--genetics
Receptor, ErbB-3--antagonists & inhibitors
Signal Transduction--drug effects
Treatment Outcome