pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion.

Iovino, Federico

pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion. [electronic resource] - The Journal of experimental medicine 06 2017 - 1619-1630 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1540-9538

10.1084/jem.20161668 doi


Adhesins, Bacterial--metabolism
Animals
Antibodies, Bacterial--pharmacology
Bacterial Proteins--metabolism
Biopsy
Blood-Brain Barrier--drug effects
Brain--drug effects
Endothelial Cells--drug effects
Fimbriae Proteins--metabolism
Humans
Meningitis, Bacterial--drug therapy
Mice, Inbred C57BL
Microscopy
Platelet Endothelial Cell Adhesion Molecule-1--metabolism
Protein Binding--drug effects
Receptors, Polymeric Immunoglobulin--metabolism
Streptococcus pneumoniae--isolation & purification
Virulence Factors--metabolism