Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.
Seo, Tadahiko
Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo. [electronic resource] - The FEBS journal 06 2017 - 1657-1671 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1742-4658
10.1111/febs.14066 doi
ADAM Proteins--metabolism
ADAM12 Protein--metabolism
Amino Acid Sequence
Animals
Antibodies, Neutralizing--pharmacology
Apoptosis Regulatory Proteins--metabolism
Cell Adhesion--drug effects
Crotalid Venoms--metabolism
Drug Resistance
Fibrinogen--metabolism
Fibronectins--metabolism
HeLa Cells
Hemorrhage--chemically induced
Human Umbilical Vein Endothelial Cells
Humans
Hydrophobic and Hydrophilic Interactions
Low Density Lipoprotein Receptor-Related Protein-5--chemistry
Low Density Lipoprotein Receptor-Related Protein-6--chemistry
Male
Membrane Proteins--metabolism
Metalloendopeptidases--metabolism
Mice
Models, Molecular
Molecular Docking Simulation
Protein Domains
Protein Structure, Secondary--drug effects
Recombinant Proteins--metabolism
Sequence Alignment
Sequence Homology, Amino Acid
Species Specificity
Vertebrates--metabolism
Wnt Signaling Pathway--drug effects
Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo. [electronic resource] - The FEBS journal 06 2017 - 1657-1671 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1742-4658
10.1111/febs.14066 doi
ADAM Proteins--metabolism
ADAM12 Protein--metabolism
Amino Acid Sequence
Animals
Antibodies, Neutralizing--pharmacology
Apoptosis Regulatory Proteins--metabolism
Cell Adhesion--drug effects
Crotalid Venoms--metabolism
Drug Resistance
Fibrinogen--metabolism
Fibronectins--metabolism
HeLa Cells
Hemorrhage--chemically induced
Human Umbilical Vein Endothelial Cells
Humans
Hydrophobic and Hydrophilic Interactions
Low Density Lipoprotein Receptor-Related Protein-5--chemistry
Low Density Lipoprotein Receptor-Related Protein-6--chemistry
Male
Membrane Proteins--metabolism
Metalloendopeptidases--metabolism
Mice
Models, Molecular
Molecular Docking Simulation
Protein Domains
Protein Structure, Secondary--drug effects
Recombinant Proteins--metabolism
Sequence Alignment
Sequence Homology, Amino Acid
Species Specificity
Vertebrates--metabolism
Wnt Signaling Pathway--drug effects