Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity.

Saleheen, Danish

Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. [electronic resource] - Nature 04 2017 - 235-239 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1476-4687

10.1038/nature22034 doi


1-Alkyl-2-acetylglycerophosphocholine Esterase--deficiency
Apolipoprotein C-III--deficiency
Cohort Studies
Consanguinity
Coronary Disease--blood
Cytochrome P450 Family 2--genetics
DNA Mutational Analysis
Dietary Fats--pharmacology
Exome--genetics
Fasting--blood
Female
Gene Deletion
Gene Frequency
Genes--genetics
Genetic Association Studies--methods
Homozygote
Humans
Interleukin-8--blood
Male
Middle Aged
Myocardial Infarction--blood
Neuregulins--genetics
Pakistan
Pedigree
Phenotype
Phosphoproteins--genetics
Postprandial Period
RNA Splice Sites--genetics
Reverse Genetics--methods
Sodium-Hydrogen Exchangers--genetics
Triglycerides--blood