Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis.
Xue, Jian-Feng
Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis. [electronic resource] - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie May 2017 - 1252-1261 p. digital
Publication Type: Journal Article
1950-6007
10.1016/j.biopha.2017.01.130 doi
Animals
Autophagy--physiology
Chondrocytes--metabolism
Disease Models, Animal
Inflammation--metabolism
Interleukin-1beta--metabolism
Male
Osteoarthritis--metabolism
Phosphatidylinositol 3-Kinases--metabolism
Phosphoinositide-3 Kinase Inhibitors
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
Rats
Rats, Sprague-Dawley
Signal Transduction--physiology
TOR Serine-Threonine Kinases--antagonists & inhibitors
Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis. [electronic resource] - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie May 2017 - 1252-1261 p. digital
Publication Type: Journal Article
1950-6007
10.1016/j.biopha.2017.01.130 doi
Animals
Autophagy--physiology
Chondrocytes--metabolism
Disease Models, Animal
Inflammation--metabolism
Interleukin-1beta--metabolism
Male
Osteoarthritis--metabolism
Phosphatidylinositol 3-Kinases--metabolism
Phosphoinositide-3 Kinase Inhibitors
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
Rats
Rats, Sprague-Dawley
Signal Transduction--physiology
TOR Serine-Threonine Kinases--antagonists & inhibitors