Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking.

Ito, Kaori

Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking. [electronic resource] - European journal of pharmacology Mar 2017 - 16-25 p. digital

Publication Type: Journal Article

1879-0712

10.1016/j.ejphar.2017.02.001 doi


Amyloid Precursor Protein Secretases--metabolism
Amyloid beta-Peptides--biosynthesis
Animals
Aspartic Acid Endopeptidases--metabolism
Brain--cytology
Endocytosis--drug effects
Memantine--pharmacology
Mice
Neurons--drug effects
Peptide Fragments--biosynthesis
Protein Transport--drug effects
Rats
Receptors, N-Methyl-D-Aspartate--metabolism
Solubility