In vivo direct reprogramming of liver cells to insulin producing cells by virus-free overexpression of defined factors.

Yang, Xiao-Fei

In vivo direct reprogramming of liver cells to insulin producing cells by virus-free overexpression of defined factors. [electronic resource] - Endocrine journal Mar 2017 - 291-302 p. digital

Publication Type: Journal Article

1348-4540

10.1507/endocrj.EJ16-0463 doi


Animals
Basic Helix-Loop-Helix Transcription Factors--genetics
Biomarkers--blood
Blood Glucose--analysis
Cell Transdifferentiation
Diabetes Mellitus, Experimental--blood
Gene Transfer Techniques--adverse effects
Hepatocytes--metabolism
Homeodomain Proteins--genetics
Hydrodynamics
Injections, Intravenous
Insulin--blood
Insulin Secretion
Insulin-Secreting Cells--metabolism
Maf Transcription Factors, Large--genetics
Male
Mice, Inbred C57BL
Nerve Tissue Proteins--genetics
Plasmids--administration & dosage
RNA, Messenger--metabolism
Specific Pathogen-Free Organisms
Tail
Trans-Activators--genetics
Up-Regulation
Urocortins--genetics