Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria.

Steffen, Janos

Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria. [electronic resource] - Molecular biology of the cell Mar 2017 - 600-612 p. digital

Publication Type: Journal Article

1939-4586

10.1091/mbc.E16-07-0545 doi


Apoptosis--physiology
Autophagy--physiology
GTP Phosphohydrolases--metabolism
HEK293 Cells
HeLa Cells
Humans
Mitochondria--metabolism
Mitochondrial Dynamics--physiology
Mitochondrial Membrane Transport Proteins--metabolism
Mitochondrial Membranes--metabolism
Mitochondrial Proteins--metabolism
Phosphate Transport Proteins--metabolism
Proteasome Endopeptidase Complex--metabolism
Proteolysis
Ubiquitin--metabolism
Ubiquitin-Protein Ligases--metabolism
Ubiquitination