X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT.
Topiol, Sid
X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT. [electronic resource] - Bioorganic & medicinal chemistry letters 02 2017 - 470-478 p. digital
Publication Type: Journal Article
1464-3405
10.1016/j.bmcl.2016.12.037 doi
Allosteric Site
Binding Sites
Citalopram--analogs & derivatives
Crystallography, X-Ray
Drug Design
Humans
Inhibitory Concentration 50
Molecular Dynamics Simulation
Protein Structure, Tertiary
Serotonin Plasma Membrane Transport Proteins--chemistry
Selective Serotonin Reuptake Inhibitors--chemical synthesis
Stereoisomerism
Structure-Activity Relationship
X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT. [electronic resource] - Bioorganic & medicinal chemistry letters 02 2017 - 470-478 p. digital
Publication Type: Journal Article
1464-3405
10.1016/j.bmcl.2016.12.037 doi
Allosteric Site
Binding Sites
Citalopram--analogs & derivatives
Crystallography, X-Ray
Drug Design
Humans
Inhibitory Concentration 50
Molecular Dynamics Simulation
Protein Structure, Tertiary
Serotonin Plasma Membrane Transport Proteins--chemistry
Selective Serotonin Reuptake Inhibitors--chemical synthesis
Stereoisomerism
Structure-Activity Relationship