Peanut sprout extract attenuates cisplatin-induced ototoxicity by induction of the Akt/Nrf2-mediated redox pathway.

Youn, Cha Kyung

Peanut sprout extract attenuates cisplatin-induced ototoxicity by induction of the Akt/Nrf2-mediated redox pathway. [electronic resource] - International journal of pediatric otorhinolaryngology Jan 2017 - 61-66 p. digital

Publication Type: Journal Article

1872-8464

10.1016/j.ijporl.2016.11.004 doi


Animals
Antineoplastic Agents--toxicity
Apoptosis--drug effects
Arachis
Blotting, Western
Caspases--drug effects
Catalase--drug effects
Cell Line
Cell Survival--drug effects
Cisplatin--toxicity
Glutamate-Cysteine Ligase--drug effects
Glutathione Peroxidase--drug effects
Hair Cells, Auditory--drug effects
Heme Oxygenase-1--drug effects
In Vitro Techniques
Labyrinth Supporting Cells--drug effects
Membrane Proteins--drug effects
Mice
Mitochondria--drug effects
NAD(P)H Dehydrogenase (Quinone)--drug effects
NF-E2-Related Factor 2--drug effects
Oxidation-Reduction--drug effects
Plant Extracts--pharmacology
Poly(ADP-ribose) Polymerases--drug effects
Proto-Oncogene Proteins c-bcl-2--drug effects
Reactive Oxygen Species--metabolism
Real-Time Polymerase Chain Reaction
Seedlings
Up-Regulation