Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.
Pomeroy, E J
Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia. [electronic resource] - Oncogene 06 2017 - 3263-3273 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1476-5594
10.1038/onc.2016.471 doi
Animals
Apoptosis
Biomarkers, Tumor--genetics
Cell Proliferation
Female
GTP Phosphohydrolases--genetics
Gene Expression Regulation, Neoplastic
Humans
Leukemia, Experimental--genetics
Leukemia, Myeloid, Acute--genetics
Male
Membrane Proteins--genetics
Mice
Mice, SCID
Mitogen-Activated Protein Kinases--genetics
Monomeric GTP-Binding Proteins--genetics
Mutation--genetics
Neoplasm Invasiveness
Oncogenes
Signal Transduction
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
ral GTP-Binding Proteins--genetics
Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia. [electronic resource] - Oncogene 06 2017 - 3263-3273 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1476-5594
10.1038/onc.2016.471 doi
Animals
Apoptosis
Biomarkers, Tumor--genetics
Cell Proliferation
Female
GTP Phosphohydrolases--genetics
Gene Expression Regulation, Neoplastic
Humans
Leukemia, Experimental--genetics
Leukemia, Myeloid, Acute--genetics
Male
Membrane Proteins--genetics
Mice
Mice, SCID
Mitogen-Activated Protein Kinases--genetics
Monomeric GTP-Binding Proteins--genetics
Mutation--genetics
Neoplasm Invasiveness
Oncogenes
Signal Transduction
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
ral GTP-Binding Proteins--genetics