Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats.

Moorman, David E

Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats. [electronic resource] - Brain research Jan 2017 - 34-42 p. digital

Publication Type: Journal Article

1872-6240

10.1016/j.brainres.2016.10.018 doi


Alcohol Drinking--drug therapy
Alcohol-Related Disorders--drug therapy
Animals
Animals, Outbred Strains
Benzoxazoles--pharmacology
Central Nervous System Depressants--administration & dosage
Conditioning, Operant--drug effects
Cues
Disease Models, Animal
Drug-Seeking Behavior--drug effects
Ethanol--administration & dosage
Male
Motivation--drug effects
Naphthyridines
Orexin Receptor Antagonists--pharmacology
Orexin Receptors--metabolism
Rats, Sprague-Dawley
Self Administration
Urea--analogs & derivatives