Cross-Neutralising Nanobodies Bind to a Conserved Pocket in the Hemagglutinin Stem Region Identified Using Yeast Display and Deep Mutational Scanning.

Gaiotto, Tiziano

Cross-Neutralising Nanobodies Bind to a Conserved Pocket in the Hemagglutinin Stem Region Identified Using Yeast Display and Deep Mutational Scanning. [electronic resource] - PloS one 2016 - e0164296 p. digital

Publication Type: Journal Article

1932-6203

10.1371/journal.pone.0164296 doi


Amino Acid Sequence
Antibodies, Monoclonal--immunology
Antibodies, Neutralizing--immunology
Antigen-Antibody Reactions
Epitope Mapping
Epitopes--immunology
Hemagglutinin Glycoproteins, Influenza Virus--genetics
Humans
Hydrogen-Ion Concentration
Influenza A Virus, H1N1 Subtype--metabolism
Molecular Sequence Data
Mutagenesis
Peptide Library
Protein Structure, Tertiary
Saccharomyces cerevisiae--metabolism
Sequence Analysis, DNA
Single-Domain Antibodies--immunology
Surface Plasmon Resonance
Temperature