Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice.
Sawicka, Kirsty
Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America 10 2016 - E6290-E6297 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1610812113 doi
Animals
Cerebral Cortex--metabolism
DNA-Binding Proteins--metabolism
Disease Models, Animal
Epilepsy, Reflex--drug therapy
Extracellular Signal-Regulated MAP Kinases--metabolism
Fragile X Mental Retardation Protein--genetics
Fragile X Syndrome--complications
Mice
Mice, Knockout
Neurons--metabolism
Phosphatidylinositol 3-Kinases--metabolism
Phosphorylation
Ribosomal Protein S6 Kinases, 90-kDa--antagonists & inhibitors
Seizures--etiology
Signal Transduction
Synapses--metabolism
TOR Serine-Threonine Kinases--metabolism
Transcription Factors--metabolism
Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America 10 2016 - E6290-E6297 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1610812113 doi
Animals
Cerebral Cortex--metabolism
DNA-Binding Proteins--metabolism
Disease Models, Animal
Epilepsy, Reflex--drug therapy
Extracellular Signal-Regulated MAP Kinases--metabolism
Fragile X Mental Retardation Protein--genetics
Fragile X Syndrome--complications
Mice
Mice, Knockout
Neurons--metabolism
Phosphatidylinositol 3-Kinases--metabolism
Phosphorylation
Ribosomal Protein S6 Kinases, 90-kDa--antagonists & inhibitors
Seizures--etiology
Signal Transduction
Synapses--metabolism
TOR Serine-Threonine Kinases--metabolism
Transcription Factors--metabolism