Distinct Effects of T-705 (Favipiravir) and Ribavirin on Influenza Virus Replication and Viral RNA Synthesis.
Vanderlinden, Evelien
Distinct Effects of T-705 (Favipiravir) and Ribavirin on Influenza Virus Replication and Viral RNA Synthesis. [electronic resource] - Antimicrobial agents and chemotherapy 11 2016 - 6679-6691 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1098-6596
10.1128/AAC.01156-16 doi
A549 Cells
Amides--chemistry
Animals
Antiviral Agents--chemistry
Chick Embryo
DNA-Directed RNA Polymerases--antagonists & inhibitors
Dogs
Gene Expression Regulation, Viral
Humans
IMP Dehydrogenase--antagonists & inhibitors
Influenza A Virus, H1N1 Subtype--drug effects
Influenza A Virus, H3N2 Subtype--drug effects
Madin Darby Canine Kidney Cells
Mutation--drug effects
Pyrazines--chemistry
RNA, Viral--antagonists & inhibitors
Reassortant Viruses--drug effects
Ribavirin--chemistry
Sequence Analysis, RNA
Structure-Activity Relationship
Viral Proteins--antagonists & inhibitors
Virus Replication--drug effects
Distinct Effects of T-705 (Favipiravir) and Ribavirin on Influenza Virus Replication and Viral RNA Synthesis. [electronic resource] - Antimicrobial agents and chemotherapy 11 2016 - 6679-6691 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1098-6596
10.1128/AAC.01156-16 doi
A549 Cells
Amides--chemistry
Animals
Antiviral Agents--chemistry
Chick Embryo
DNA-Directed RNA Polymerases--antagonists & inhibitors
Dogs
Gene Expression Regulation, Viral
Humans
IMP Dehydrogenase--antagonists & inhibitors
Influenza A Virus, H1N1 Subtype--drug effects
Influenza A Virus, H3N2 Subtype--drug effects
Madin Darby Canine Kidney Cells
Mutation--drug effects
Pyrazines--chemistry
RNA, Viral--antagonists & inhibitors
Reassortant Viruses--drug effects
Ribavirin--chemistry
Sequence Analysis, RNA
Structure-Activity Relationship
Viral Proteins--antagonists & inhibitors
Virus Replication--drug effects