CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia.

Guerra, Borja

CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia. [electronic resource] - Oncotarget 05 2017 - 29679-29698 p. digital

Publication Type: Journal Article

1949-2553

10.18632/oncotarget.11425 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Cycle--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
Disease Models, Animal
Drug Resistance, Neoplasm--drug effects
Female
Fusion Proteins, bcr-abl--genetics
Humans
Imatinib Mesylate--pharmacology
JNK Mitogen-Activated Protein Kinases--metabolism
K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy
Mice
Naphthoquinones--pharmacology
Protein Kinase Inhibitors--pharmacology
STAT5 Transcription Factor--metabolism
Signal Transduction
Xenograft Model Antitumor Assays