Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument.

Furet, Pascal

Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument. [electronic resource] - Bioorganic & medicinal chemistry letters 10 2016 - 4837-4841 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2016.08.010 doi


Crystallography, X-Ray
Drug Discovery
Fluorescence Resonance Energy Transfer
Molecular Conformation
Proto-Oncogene Proteins c-mdm2--antagonists & inhibitors
Tumor Suppressor Protein p53--antagonists & inhibitors