Optimization of Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for Duration of Action, as an Inhaled Therapy for Lung Remodeling in Pulmonary Arterial Hypertension.

Shaw, Duncan E

Optimization of Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for Duration of Action, as an Inhaled Therapy for Lung Remodeling in Pulmonary Arterial Hypertension. [electronic resource] - Journal of medicinal chemistry 09 2016 - 7901-14 p. digital

Publication Type: Journal Article

1520-4804

10.1021/acs.jmedchem.6b00703 doi


Administration, Inhalation
Airway Remodeling--drug effects
Animals
Cell Line
Cell Proliferation
Hypertension, Pulmonary--drug therapy
Lung--blood supply
Membranes, Artificial
Molecular Docking Simulation
Muscle, Smooth, Vascular--drug effects
Niacinamide--analogs & derivatives
Permeability
Proto-Oncogene Proteins c-kit--antagonists & inhibitors
Pyrazoles--chemical synthesis
Rats
Receptor, Platelet-Derived Growth Factor alpha--antagonists & inhibitors
Receptor, Platelet-Derived Growth Factor beta--antagonists & inhibitors
Receptors, Platelet-Derived Growth Factor--antagonists & inhibitors
Structure-Activity Relationship
Vascular Remodeling--drug effects