Slow infusion rate of doxorubicin induces higher pro-inflammatory cytokine production.

Tien, Chin-Chieh

Slow infusion rate of doxorubicin induces higher pro-inflammatory cytokine production. [electronic resource] - Regulatory toxicology and pharmacology : RTP Nov 2016 - 69-76 p. digital

Publication Type: Comparative Study; Journal Article

1096-0295

10.1016/j.yrtph.2016.08.002 doi


Animals
Antibiotics, Antineoplastic--administration & dosage
Biomarkers--blood
Cardiotoxicity
Chemical and Drug Induced Liver Injury--blood
Cytokines--blood
Dose-Response Relationship, Drug
Doxorubicin--administration & dosage
Heart--drug effects
Heart Diseases--blood
Inflammation--blood
Inflammation Mediators--blood
Infusions, Intravenous
Interleukin-6--blood
Kidney--drug effects
Kidney Diseases--blood
Liver--drug effects
Male
Myocardium--metabolism
Rats, Inbred WKY
Time Factors
Tumor Necrosis Factor-alpha--blood