Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair.

Christmann, Markus

Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair. [electronic resource] - Oncotarget Apr 2017 - 27754-27771 p. digital

Publication Type: Journal Article

1949-2553

10.18632/oncotarget.10897 doi


Animals
Antineoplastic Agents, Alkylating--pharmacology
Apoptosis--drug effects
Apoptosis Regulatory Proteins--metabolism
Brain Neoplasms--drug therapy
Cell Line, Tumor
Cell Proliferation--drug effects
DNA Breaks, Double-Stranded--drug effects
Dacarbazine--analogs & derivatives
Down-Regulation
Drug Resistance, Neoplasm--genetics
Flow Cytometry
Gene Knockdown Techniques
Glioblastoma--drug therapy
Humans
Integrin alphaVbeta3--antagonists & inhibitors
Integrin beta3--genetics
Mice
Mice, Inbred BALB C
Mice, Nude
NF-KappaB Inhibitor alpha--metabolism
Neoplasm Grading
Peptides, Cyclic--pharmacology
Phosphorylation
Proto-Oncogene Proteins c-akt--metabolism
RNA Interference
RNA, Small Interfering--metabolism
Rad51 Recombinase--genetics
Receptor-Interacting Protein Serine-Threonine Kinases--metabolism
Receptors, Vitronectin--antagonists & inhibitors
Recombinational DNA Repair
Signal Transduction
Temozolomide
Xenograft Model Antitumor Assays