Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors.

Donato, E

Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors. [electronic resource] - Leukemia 02 2017 - 479-490 p. digital

Publication Type: Journal Article

1476-5551

10.1038/leu.2016.182 doi


Azepines--pharmacology
Cell Cycle--drug effects
Cell Cycle Proteins
Cell Line, Tumor
Cell Proliferation--drug effects
Chromatin--genetics
Cyclin-Dependent Kinase 9--metabolism
E2F Transcription Factors--metabolism
Enhancer Elements, Genetic
Gene Expression Regulation, Neoplastic--drug effects
Humans
Neoplasms--genetics
Nuclear Proteins--metabolism
Promoter Regions, Genetic
Protein Binding
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-myc--genetics
RNA Polymerase II--metabolism
Transcription Factors--metabolism
Transcription, Genetic
Triazoles--pharmacology