In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs).

Gallagher, Erin

In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs). [electronic resource] - Fluids and barriers of the CNS Jul 2016 - 10 p. digital

Publication Type: Journal Article

2045-8118

10.1186/s12987-016-0035-0 doi


Acetylcholinesterase--metabolism
Animals
Biological Transport--drug effects
Brain--blood supply
Capillary Permeability--drug effects
Cell Line
Cholinesterase Inhibitors--pharmacology
Cholinesterase Reactivators--pharmacokinetics
Dogs
Dose-Response Relationship, Drug
Drug Interactions
Endothelial Cells--drug effects
Fluorescent Dyes--pharmacokinetics
Humans
Microvessels--drug effects
Paraoxon--pharmacology
Parathion--pharmacology
Pralidoxime Compounds--pharmacokinetics
Rhodamine 123--pharmacokinetics