Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile.

Strelnik, Alexey D

Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile. [electronic resource] - Bioorganic & medicinal chemistry letters 08 2016 - 4092-4 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1464-3405

10.1016/j.bmcl.2016.06.070 doi


Acetylcholinesterase--chemistry
Animals
Butyrylcholinesterase--chemistry
Cholinesterase Inhibitors--chemistry
Lethal Dose 50
Mice
Protein Binding
Pyridostigmine Bromide--analogs & derivatives
Pyridoxine--chemistry
Structure-Activity Relationship
Toxicity Tests, Acute