Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.

Posey, Avery D

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma. [electronic resource] - Immunity 06 2016 - 1444-54 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

1097-4180

10.1016/j.immuni.2016.05.014 doi


Adenocarcinoma--immunology
Animals
Cell Line, Tumor
Cytotoxicity, Immunologic
Epitopes, T-Lymphocyte--immunology
Genetic Engineering
Glycosylation
Humans
Immunotherapy--methods
Jurkat Cells
Mice
Mice, Inbred Strains
Mucin-1--chemistry
Receptors, Antigen, T-Cell--genetics
Recombinant Fusion Proteins--genetics
T-Lymphocytes--physiology
Xenograft Model Antitumor Assays