New insights into the regulatory pathways associated with the activation of the stringent response in bacterial resistance to the PBP2-targeted antibiotics, mecillinam and OP0595/RG6080.

Doumith, M

New insights into the regulatory pathways associated with the activation of the stringent response in bacterial resistance to the PBP2-targeted antibiotics, mecillinam and OP0595/RG6080. [electronic resource] - The Journal of antimicrobial chemotherapy 10 2016 - 2810-4 p. digital

Publication Type: Journal Article

1460-2091

10.1093/jac/dkw230 doi


Amdinocillin--metabolism
Anti-Bacterial Agents--pharmacology
Azabicyclo Compounds--metabolism
Bacterial Proteins--genetics
Drug Resistance, Multiple, Bacterial--genetics
Escherichia coli--cytology
Escherichia coli Proteins--antagonists & inhibitors
Gene Expression Regulation, Bacterial
Genetic Variation
Genome, Bacterial
High-Throughput Nucleotide Sequencing
Lactams--metabolism
Microscopy, Electron, Transmission
Mutation
Penicillin-Binding Proteins--antagonists & inhibitors
Sigma Factor--genetics
beta-Lactamase Inhibitors--metabolism