Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection.

Stec, Jozef

Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection. [electronic resource] - Journal of medicinal chemistry 07 2016 - 6232-47 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/acs.jmedchem.6b00415 doi


Animals
Antitubercular Agents--chemistry
Bacterial Proteins--antagonists & inhibitors
Disease Models, Animal
Drug Design
Female
Humans
Indoles--chemistry
Membrane Transport Proteins--metabolism
Mice, Inbred BALB C
Microbial Sensitivity Tests
Models, Molecular
Molecular Docking Simulation
Molecular Targeted Therapy
Mycobacterium tuberculosis--drug effects
Tuberculosis--drug therapy
Tuberculosis, Multidrug-Resistant--drug therapy