A Novel HSP90 Inhibitor-Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer.

Gaponova, Anna V

A Novel HSP90 Inhibitor-Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Oct 2016 - 5120-5129 p. digital

Publication Type: Journal Article

1557-3265

10.1158/1078-0432.CCR-15-3068 doi


Animals
Antineoplastic Agents, Phytogenic--therapeutic use
Apoptosis--drug effects
Camptothecin--analogs & derivatives
Carboplatin--therapeutic use
Cell Cycle Checkpoints--drug effects
Cell Line, Tumor
DNA Damage--drug effects
Drug Delivery Systems--methods
Drug Synergism
Female
HSP90 Heat-Shock Proteins--antagonists & inhibitors
Humans
Irinotecan
Lung Neoplasms--drug therapy
Mice
Mice, SCID
Resorcinols--therapeutic use
Signal Transduction--drug effects
Small Cell Lung Carcinoma--drug therapy
Xenograft Model Antitumor Assays