Targeting IκB Kinase β/NF-κB Signaling in Human Prostate Cancer by a Novel IκB Kinase β Inhibitor CmpdA.

Zhang, Yanting

Targeting IκB Kinase β/NF-κB Signaling in Human Prostate Cancer by a Novel IκB Kinase β Inhibitor CmpdA. [electronic resource] - Molecular cancer therapeutics 07 2016 - 1504-14 p. digital

Publication Type: Journal Article

1538-8514

10.1158/1535-7163.MCT-15-0999 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Cell Movement--genetics
Cell Transformation, Neoplastic--drug effects
Disease Models, Animal
Docetaxel
Drug Synergism
Epithelial-Mesenchymal Transition--genetics
Gene Knockdown Techniques
Humans
I-kappa B Kinase--genetics
Male
Mechanistic Target of Rapamycin Complex 1
Mice
Multiprotein Complexes--metabolism
NF-kappa B--genetics
Neoplastic Stem Cells--drug effects
Phosphorylation
Prostatic Neoplasms--genetics
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-akt--metabolism
Signal Transduction--drug effects
TOR Serine-Threonine Kinases--metabolism
Taxoids--pharmacology
Xenograft Model Antitumor Assays