Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.

Toyn, Jeremy H

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects. [electronic resource] - The Journal of pharmacology and experimental therapeutics 07 2016 - 125-37 p. digital

Publication Type: Journal Article

1521-0103

10.1124/jpet.116.232249 doi


Amyloid Precursor Protein Secretases--metabolism
Amyloid beta-Peptides--antagonists & inhibitors
Aniline Compounds--chemistry
Animals
Brain--drug effects
Bridged-Ring Compounds--chemistry
Cell Line
Dogs
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Female
Humans
Macaca fascicularis
Pyrimidines--chemistry
Rats, Sprague-Dawley
Receptors, Notch--metabolism
Species Specificity
Tissue Distribution