Alisertib induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells.

Fu, Yunfeng

Alisertib induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. [electronic resource] - Molecular medicine reports Jul 2016 - 394-8 p. digital

Publication Type: Journal Article

1791-3004

10.3892/mmr.2016.5249 doi


AMP-Activated Protein Kinases--metabolism
Apoptosis--drug effects
Autophagy--drug effects
Azepines--chemistry
Cell Line, Tumor
Cell Survival--drug effects
Humans
Leukemia
Protein Kinase Inhibitors--chemistry
Proto-Oncogene Proteins c-akt--metabolism
Pyrimidines--chemistry
Signal Transduction--drug effects
TOR Serine-Threonine Kinases--metabolism
p38 Mitogen-Activated Protein Kinases--metabolism