Design and synthesis of novel pyrazolo[1,5-a]pyrimidine derivatives bearing nitrogen mustard moiety and evaluation of their antitumor activity in vitro and in vivo.

Zhao, Mingxia

Design and synthesis of novel pyrazolo[1,5-a]pyrimidine derivatives bearing nitrogen mustard moiety and evaluation of their antitumor activity in vitro and in vivo. [electronic resource] - European journal of medicinal chemistry Aug 2016 - 183-96 p. digital

Publication Type: Journal Article

1768-3254

10.1016/j.ejmech.2016.04.068 doi


Animals
Antineoplastic Agents--chemical synthesis
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Chemistry Techniques, Synthetic
Drug Design
Drug Screening Assays, Antitumor
Female
Humans
Mechlorethamine--chemistry
Mice
Pyrimidines--chemical synthesis