5-Fluorouracil inhibits dihydrofolate reductase precursor mRNA processing and/or nuclear mRNA stability in methotrexate-resistant KB cells.

Will, C L

5-Fluorouracil inhibits dihydrofolate reductase precursor mRNA processing and/or nuclear mRNA stability in methotrexate-resistant KB cells. [electronic resource] - The Journal of biological chemistry Dec 1989 - 21413-21 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0021-9258


Blotting, Northern
Cell Nucleus--drug effects
Drug Resistance
Exons
Fluorouracil--pharmacology
Gene Amplification
Genes
Humans
Introns
KB Cells
Kinetics
Methotrexate--pharmacology
Plasmids
RNA Precursors--drug effects
RNA Processing, Post-Transcriptional--drug effects
RNA, Messenger--drug effects
Restriction Mapping
Tetrahydrofolate Dehydrogenase--genetics