TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting.

Fountzilas, George

TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting. [electronic resource] - Oncotarget May 2016 - 32731-53 p. digital

Publication Type: Journal Article; Multicenter Study

1949-2553

10.18632/oncotarget.9022 doi


Adult
Aged
Aged, 80 and over
Antineoplastic Agents, Immunological--therapeutic use
Biomarkers, Tumor--analysis
Chemotherapy, Adjuvant
Chi-Square Distribution
Class I Phosphatidylinositol 3-Kinases--analysis
Clinical Trials as Topic
DNA Mutational Analysis
Disease Progression
Disease-Free Survival
Female
Genetic Predisposition to Disease
Greece
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Middle Aged
Multivariate Analysis
Mutation
Patient Selection
Phenotype
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
Retrospective Studies
Risk Factors
Time Factors
Trastuzumab--therapeutic use
Treatment Outcome
Triple Negative Breast Neoplasms--chemistry
Tumor Suppressor Protein p53--analysis
Young Adult