A randomized, open-label 3-way crossover study to investigate the relative bioavailability and bioequivalence of crushed sildenafil 20 mg tablets mixed with apple sauce, extemporaneously prepared suspension (EP), and intact sildenafil 20 mg tablets in healthy volunteers under fasting conditions.
Gao, Xiang
A randomized, open-label 3-way crossover study to investigate the relative bioavailability and bioequivalence of crushed sildenafil 20 mg tablets mixed with apple sauce, extemporaneously prepared suspension (EP), and intact sildenafil 20 mg tablets in healthy volunteers under fasting conditions. [electronic resource] - Clinical pharmacology in drug development 01 2015 - 74-80 p. digital
Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
2160-7648
10.1002/cpdd.146 doi
Administration, Oral
Adult
Area Under Curve
Belgium
Biological Availability
Cross-Over Studies
Drug Compounding
Fasting--blood
Female
Fruit
Half-Life
Healthy Volunteers
Humans
Male
Malus
Metabolic Clearance Rate
Middle Aged
Models, Biological
Pharmaceutical Solutions
Phosphodiesterase 5 Inhibitors--administration & dosage
Sildenafil Citrate--administration & dosage
Tablets
Therapeutic Equivalency
Young Adult
A randomized, open-label 3-way crossover study to investigate the relative bioavailability and bioequivalence of crushed sildenafil 20 mg tablets mixed with apple sauce, extemporaneously prepared suspension (EP), and intact sildenafil 20 mg tablets in healthy volunteers under fasting conditions. [electronic resource] - Clinical pharmacology in drug development 01 2015 - 74-80 p. digital
Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
2160-7648
10.1002/cpdd.146 doi
Administration, Oral
Adult
Area Under Curve
Belgium
Biological Availability
Cross-Over Studies
Drug Compounding
Fasting--blood
Female
Fruit
Half-Life
Healthy Volunteers
Humans
Male
Malus
Metabolic Clearance Rate
Middle Aged
Models, Biological
Pharmaceutical Solutions
Phosphodiesterase 5 Inhibitors--administration & dosage
Sildenafil Citrate--administration & dosage
Tablets
Therapeutic Equivalency
Young Adult