Functional characterization of six aspartate (D) recombinant mojastin mutants (r-Moj): A second aspartate amino acid carboxyl to the RGD in r-Moj-D_ peptides is not sufficient to induce apoptosis of SK-Mel-28 cells.

Ramos, Carla J

Functional characterization of six aspartate (D) recombinant mojastin mutants (r-Moj): A second aspartate amino acid carboxyl to the RGD in r-Moj-D_ peptides is not sufficient to induce apoptosis of SK-Mel-28 cells. [electronic resource] - Toxicon : official journal of the International Society on Toxinology Aug 2016 - 36-42 p. digital

Publication Type: Comparative Study; Journal Article

1879-3150

10.1016/j.toxicon.2016.04.038 doi


Amino Acid Motifs
Animals
Antineoplastic Agents--chemistry
Apoptosis--drug effects
Aspartic Acid--chemistry
Cell Line, Tumor
Cell Movement--drug effects
Cell Proliferation--drug effects
Disintegrins--genetics
Drug Design
Enzyme Repression--drug effects
Humans
Integrin alpha Chains--antagonists & inhibitors
Integrin alphaV--chemistry
Melanoma--drug therapy
Mutant Proteins--chemistry
Peptide Fragments--antagonists & inhibitors
RNA Interference
Recombinant Proteins--chemistry
Reptilian Proteins--antagonists & inhibitors
Viper Venoms--chemistry
rac1 GTP-Binding Protein--antagonists & inhibitors