Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-associated fibroblast differentiation.

Coleman, David T

Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-associated fibroblast differentiation. [electronic resource] - Oncotarget May 2016 - 32200-9 p. digital

Publication Type: Journal Article

1949-2553

10.18632/oncotarget.8609 doi


Antineoplastic Agents--pharmacology
Calcium Signaling--drug effects
Cancer-Associated Fibroblasts--drug effects
Cardiac Glycosides--pharmacology
Cell Differentiation--drug effects
Cell Line, Tumor
Cell Shape--drug effects
Cell Survival--drug effects
Dose-Response Relationship, Drug
Drug Repositioning
Fibronectins--metabolism
Gene Expression Regulation, Neoplastic
Humans
Male
Myofibroblasts--drug effects
Promoter Regions, Genetic
Prostatic Neoplasms--drug therapy
Smad Proteins--genetics
Small Molecule Libraries
Sodium-Potassium-Exchanging ATPase--antagonists & inhibitors
Transfection
Transforming Growth Factor beta--pharmacology
Tumor Microenvironment