Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models.

You, Abin

Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models. [electronic resource] - Journal of hematology & oncology Mar 2016 - 20 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1756-8722

10.1186/s13045-016-0253-6 doi


Acetyltransferases--metabolism
Animals
Antineoplastic Agents--administration & dosage
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Apoptosis--drug effects
Basic Helix-Loop-Helix Transcription Factors--metabolism
Blotting, Western
Carcinoma, Hepatocellular--drug therapy
Cell Hypoxia
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
Drug Synergism
Epithelial-Mesenchymal Transition--drug effects
Humans
Hypoglycemic Agents--administration & dosage
Liver Neoplasms--drug therapy
Male
Metformin--administration & dosage
Mice, Inbred BALB C
Mice, Nude
Neoplasm Metastasis
Neoplasm Recurrence, Local
Niacinamide--administration & dosage
Phenylurea Compounds--administration & dosage
Sorafenib
Transcription Factors--metabolism
Xenograft Model Antitumor Assays