Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor.
Kimura, Kumi
Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor. [electronic resource] - Cell reports Mar 2016 - 2362-74 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2211-1247
10.1016/j.celrep.2016.02.032 doi
Acetylcholine--metabolism
Animals
Blood Glucose--analysis
Calcium-Binding Proteins
Cells, Cultured
Chlorisondamine--pharmacology
Diet, High-Fat
Insulin--pharmacology
Interleukin-6--blood
Kupffer Cells--cytology
Liver--metabolism
Male
Mice
Mice, Inbred C57BL
Nicotine--pharmacology
Obesity--metabolism
Phosphorylation--drug effects
Protein Binding--drug effects
Receptors, Cell Surface--genetics
Receptors, G-Protein-Coupled
STAT3 Transcription Factor--metabolism
Signal Transduction--drug effects
Vagus Nerve--drug effects
alpha7 Nicotinic Acetylcholine Receptor--deficiency
Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor. [electronic resource] - Cell reports Mar 2016 - 2362-74 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2211-1247
10.1016/j.celrep.2016.02.032 doi
Acetylcholine--metabolism
Animals
Blood Glucose--analysis
Calcium-Binding Proteins
Cells, Cultured
Chlorisondamine--pharmacology
Diet, High-Fat
Insulin--pharmacology
Interleukin-6--blood
Kupffer Cells--cytology
Liver--metabolism
Male
Mice
Mice, Inbred C57BL
Nicotine--pharmacology
Obesity--metabolism
Phosphorylation--drug effects
Protein Binding--drug effects
Receptors, Cell Surface--genetics
Receptors, G-Protein-Coupled
STAT3 Transcription Factor--metabolism
Signal Transduction--drug effects
Vagus Nerve--drug effects
alpha7 Nicotinic Acetylcholine Receptor--deficiency