Elevated Translation Initiation Factor eIF4E Is an Attractive Therapeutic Target in Multiple Myeloma.
Li, Shirong
Elevated Translation Initiation Factor eIF4E Is an Attractive Therapeutic Target in Multiple Myeloma. [electronic resource] - Molecular cancer therapeutics 04 2016 - 711-9 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1538-8514
10.1158/1535-7163.MCT-15-0798 doi
Animals
Antineoplastic Agents--pharmacology
Biomarkers
CCAAT-Enhancer-Binding Protein-beta--genetics
Cell Line, Tumor
Cell Proliferation--drug effects
Disease Models, Animal
Ectopic Gene Expression
Eukaryotic Initiation Factor-4E--antagonists & inhibitors
Female
Gene Expression
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Genes, myc
Humans
Interferon Regulatory Factors--genetics
Mice
Molecular Targeted Therapy
Multiple Myeloma--drug therapy
Neovascularization, Pathologic--drug therapy
RNA Interference
Signal Transduction--drug effects
Stromal Cells--drug effects
Tumor Burden--drug effects
Xenograft Model Antitumor Assays
Elevated Translation Initiation Factor eIF4E Is an Attractive Therapeutic Target in Multiple Myeloma. [electronic resource] - Molecular cancer therapeutics 04 2016 - 711-9 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1538-8514
10.1158/1535-7163.MCT-15-0798 doi
Animals
Antineoplastic Agents--pharmacology
Biomarkers
CCAAT-Enhancer-Binding Protein-beta--genetics
Cell Line, Tumor
Cell Proliferation--drug effects
Disease Models, Animal
Ectopic Gene Expression
Eukaryotic Initiation Factor-4E--antagonists & inhibitors
Female
Gene Expression
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Genes, myc
Humans
Interferon Regulatory Factors--genetics
Mice
Molecular Targeted Therapy
Multiple Myeloma--drug therapy
Neovascularization, Pathologic--drug therapy
RNA Interference
Signal Transduction--drug effects
Stromal Cells--drug effects
Tumor Burden--drug effects
Xenograft Model Antitumor Assays