Is sunitinib a Narrow Therapeutic Index Drug? - A systematic review and in vitro toxicology-analysis of Sunitinib vs. Imatinib in cells from different tissues.

Haas, Bodo

Is sunitinib a Narrow Therapeutic Index Drug? - A systematic review and in vitro toxicology-analysis of Sunitinib vs. Imatinib in cells from different tissues. [electronic resource] - Regulatory toxicology and pharmacology : RTP Jun 2016 - 25-34 p. digital

Publication Type: Comparative Study; Journal Article; Review; Systematic Review

1096-0295

10.1016/j.yrtph.2016.02.010 doi


Animals
Antineoplastic Agents--administration & dosage
Apoptosis--drug effects
Apoptosis Regulatory Proteins--metabolism
Cell Line, Tumor
Cell Survival--drug effects
Dose-Response Relationship, Drug
Drug and Narcotic Control
Drugs, Generic--administration & dosage
Humans
Imatinib Mesylate--administration & dosage
Indoles--administration & dosage
Inhibitory Concentration 50
Neoplasms--drug therapy
Organ Specificity
Phosphorylation
Protein Kinase Inhibitors--administration & dosage
Pyrroles--administration & dosage
Risk Assessment
Signal Transduction--drug effects
Sunitinib
Toxicity Tests--methods