Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, the Human Liver Retinoic Acid Hydroxylase.
Diaz, Philippe
Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, the Human Liver Retinoic Acid Hydroxylase. [electronic resource] - Journal of medicinal chemistry Mar 2016 - 2579-95 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.5b01780 doi
Algorithms
Animals
Cell Line, Tumor
Cytochrome P-450 Enzyme System--drug effects
Drug Design
Drug Resistance
Enzyme Induction
Enzyme Inhibitors--chemical synthesis
Humans
Isoenzymes--antagonists & inhibitors
Kinetics
Liver--drug effects
Rats
Retinoic Acid 4-Hydroxylase
Structure-Activity Relationship
Substrate Specificity
Tretinoin--metabolism
Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, the Human Liver Retinoic Acid Hydroxylase. [electronic resource] - Journal of medicinal chemistry Mar 2016 - 2579-95 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.5b01780 doi
Algorithms
Animals
Cell Line, Tumor
Cytochrome P-450 Enzyme System--drug effects
Drug Design
Drug Resistance
Enzyme Induction
Enzyme Inhibitors--chemical synthesis
Humans
Isoenzymes--antagonists & inhibitors
Kinetics
Liver--drug effects
Rats
Retinoic Acid 4-Hydroxylase
Structure-Activity Relationship
Substrate Specificity
Tretinoin--metabolism