Metformin improves the angiogenic potential of human CD34⁺ cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction.
Bakhashab, Sherin
Metformin improves the angiogenic potential of human CD34⁺ cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction. [electronic resource] - Cardiovascular diabetology Feb 2016 - 27 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1475-2840
10.1186/s12933-016-0344-2 doi
Angiogenesis Inducing Agents--pharmacology
Antigens, CD34--metabolism
Biomarkers--metabolism
Cell Hypoxia
Cells, Cultured
Chemokine CXCL10--genetics
Dose-Response Relationship, Drug
Down-Regulation
Gene Expression Profiling
Human Umbilical Vein Endothelial Cells--drug effects
Humans
Hyperglycemia--drug therapy
Hypoglycemic Agents--pharmacology
Membrane Proteins--genetics
Metformin--pharmacology
Myocardial Infarction--drug therapy
Neovascularization, Physiologic--drug effects
Oxidoreductases--genetics
Phenotype
Stem Cells--drug effects
Tissue Inhibitor of Metalloproteinase-1--genetics
Up-Regulation
Vascular Endothelial Growth Factor A--genetics
Metformin improves the angiogenic potential of human CD34⁺ cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction. [electronic resource] - Cardiovascular diabetology Feb 2016 - 27 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1475-2840
10.1186/s12933-016-0344-2 doi
Angiogenesis Inducing Agents--pharmacology
Antigens, CD34--metabolism
Biomarkers--metabolism
Cell Hypoxia
Cells, Cultured
Chemokine CXCL10--genetics
Dose-Response Relationship, Drug
Down-Regulation
Gene Expression Profiling
Human Umbilical Vein Endothelial Cells--drug effects
Humans
Hyperglycemia--drug therapy
Hypoglycemic Agents--pharmacology
Membrane Proteins--genetics
Metformin--pharmacology
Myocardial Infarction--drug therapy
Neovascularization, Physiologic--drug effects
Oxidoreductases--genetics
Phenotype
Stem Cells--drug effects
Tissue Inhibitor of Metalloproteinase-1--genetics
Up-Regulation
Vascular Endothelial Growth Factor A--genetics