DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.

Harris, Philip A

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. [electronic resource] - Journal of medicinal chemistry Mar 2016 - 2163-78 p. digital

Publication Type: Journal Article

1520-4804

10.1021/acs.jmedchem.5b01898 doi


Animals
Cell Line, Tumor
Crystallography, X-Ray
DNA--chemistry
Dose-Response Relationship, Drug
HT29 Cells
Humans
Isoxazoles--chemical synthesis
Mice
Models, Molecular
Molecular Structure
Oxazepines--chemical synthesis
Protein Kinase Inhibitors--chemical synthesis
Receptor-Interacting Protein Serine-Threonine Kinases--antagonists & inhibitors
Small Molecule Libraries--chemical synthesis
Structure-Activity Relationship
U937 Cells