c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition.

Palumbo, Camilla

c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition. [electronic resource] - Journal of translational medicine Feb 2016 - 37 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1479-5876

10.1186/s12967-016-0796-x doi


Apoptosis--drug effects
Autophagy--drug effects
Caspase 3--metabolism
Cell Line, Tumor
Cell Survival--drug effects
Enzyme Activation--drug effects
Gene Silencing--drug effects
Humans
Inhibitory Concentration 50
JNK Mitogen-Activated Protein Kinases--metabolism
Microtubule-Associated Proteins--metabolism
Osteosarcoma--metabolism
Oxadiazoles--pharmacology
Phagosomes--drug effects
RNA-Binding Proteins--metabolism
Signal Transduction--drug effects
Stress, Physiological--drug effects
TNF Receptor-Associated Factor 2--metabolism