Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression.

Klein, Claudius

Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression. [electronic resource] - The Journal of experimental medicine Feb 2016 - 273-90 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1540-9538

10.1084/jem.20150556 doi


Animals
Disease Progression
Hedgehog Proteins--metabolism
Hematopoiesis
Hematopoietic Stem Cells--metabolism
Humans
Janus Kinase 2--genetics
Leukemia--etiology
Ligands
Lymphopenia--etiology
Mice
Mice, Knockout
Mice, Transgenic
Mutant Proteins--genetics
Myeloproliferative Disorders--etiology
Osteoblasts--metabolism
Patched Receptors
Patched-2 Receptor
Phenotype
Polycythemia Vera--genetics
Receptors, Cell Surface--deficiency
Recombinant Proteins--genetics
Signal Transduction
Stem Cell Niche