A High-Affinity Native Human Antibody Disrupts Biofilm from Staphylococcus aureus Bacteria and Potentiates Antibiotic Efficacy in a Mouse Implant Infection Model.

Estellés, Angeles

A High-Affinity Native Human Antibody Disrupts Biofilm from Staphylococcus aureus Bacteria and Potentiates Antibiotic Efficacy in a Mouse Implant Infection Model. [electronic resource] - Antimicrobial agents and chemotherapy Apr 2016 - 2292-301 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1098-6596

10.1128/AAC.02588-15 doi


Amino Acid Sequence
Animals
Anti-Bacterial Agents--biosynthesis
Antibodies, Monoclonal--biosynthesis
Antibody Specificity
B-Lymphocytes--chemistry
Bacterial Proteins--antagonists & inhibitors
Biofilms--drug effects
DNA-Binding Proteins--antagonists & inhibitors
Daptomycin--pharmacology
Disease Models, Animal
Drug Therapy, Combination
Epitope Mapping
Female
Foreign Bodies--drug therapy
Gene Expression
Injections, Intraperitoneal
Integration Host Factors--antagonists & inhibitors
Methicillin-Resistant Staphylococcus aureus--drug effects
Mice
Mice, Inbred C57BL
Models, Molecular
Plankton--drug effects
Sequence Alignment
Single-Cell Analysis
Staphylococcal Infections--drug therapy